Speaking to the club's official site, the Real Madrid boss expressed his concerns and the way that his players played on the day. If he fails to make it, Fernando Llorente - who has a good record against Madrid - could be brought into the side to provide a focal point.
Isco, however, has managed to recover from a knock he suffered at the tail-end of the game at Montilivi on Sunday.
And their cause was aided hugely by an injury blow for the visitors at half-time, with Raphael Varane having not been fit to return for the second-half. However, the Real Madrid legend refuses to believe that their title chances are over. The defeat dropped the defending La Liga and Champions League champions to third place, eight points behind Barcelona after 10 games.
The four-time Ballon d'Or winner, who scooped the FIFA Best Men's Player award last week, has broken all sorts of records since his £80 million move to the Spanish capital in 2009, scoring 413 goals in 405 appearances. Through a mixture of well-calculated yet no-nonsense tackling, intense pressing of Madrid's attacking arsenal at every opportunity and a positional intelligence to effectively wipe out Cristiano Ronaldo's influence on the game, unlike the current political situation Girona looked incredibly strong and stable in defence.
In a story where they call Isco the only player who fought for a win, they focused on the negative attitudes of several players. You don't get that from Zidane.
Are Real Madrid in crisis? In the press conference afterwards, the coach went in circles, not convincing in his analysis - which is unusual for him.
Zidane's comments will certainly be reassuring to Real Madrid fans.
"It happens sometimes that you relax a little". Mauricio Pochettino admitted he didn't care too much about the League Cup weeks before the 3-2 loss to West Ham, and his charges came within a few minutes of securing a creditable draw against Manchester United.
And the voting wasn't even close. Things are bad when Spurs can cope better with key absences than Madrid can.
His self-confidence is to be admired.
Los Blancos are now a massive 8 points behind league leaders Barca and need a major change to have a chance of winning the league.