Roger Federer moved into a 12th Wimbledon semifinal and within touching distance of a record eighth title Wednesday as Andy Murray and Novak Djokovic crashed out on a dramatic day at the All England Club.
Federer is the second oldest semi-finalist after Ken Rosewall who finished runner-up in 1974 at the age of 39.
From there, Querrey hit a simple drop shot that Murray had no chance to return and let out an emphatic roar in celebration.
He wrapped up victory with his 27th booming ace.
He even managed to match Milos Raonic - who boasts the second fastest serve of the tournament at a blistering 142mph (228.5km/h) - with 11 aces in his quarter-final victory.
The hip, though, was a problem this time.
Time off has paid dividends for Roger Federer, who missed the last half of 2016 to allow his surgically repaired left knee heal, then skipped the clay-court season this year.
Yet the once dominant nation in men's tennis that has remained so in the women's game, largely thanks to the Williams sisters, has not produced a Grand Slam winner since Andy Rodddick won the US Open in 2003 and it is perhaps even more remarkable that no American man has contested a semi-final in one of those tournaments in the past eight years.
He will face Croatian seventh seed Marin Cilic.
"I didn't start my best, but I just kept with it. Kept swinging away and then really found a groove in the fourth and fifth set", Querrey said.
"I kind of noticed it (Murray's injury) a little bit from the beginning".
His serve speeds slowed in the latter stages Wednesday.
His game plan seemed to involve turning Centre Court into a firing range which brought him little success in the opening set.
Murray was clearly struggling in the final sets and was unable to cover the court with his usual energy. In Thailand for a 2009 tournament, he cut two muscles in his right arm when he sat on a glass table that shattered.
Murray claimed that in 28 minutes and there was barely a hint of his vulnerability when he broke for a 4-3 lead in the second.
Querrey, meanwhile, has reached a maiden semi-final at the majors at the 42nd time of asking.
Andy Murray winces in pain during his quarter-final defeat to USA's Sam Querrey yesterday.
The 24th-seeded American, who knocked out 2015 champion Djokovic 12 months ago, proved that was no fluke by downing defending champion Murray in the quarter-finals on Wednesday. It's sore. I tried my best.
From 1-all in the fourth, Querrey grabbed eight games in a row to take that set and lead 3-0 in the last.